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Cancer of Cervix or Cervical Cancer

High risk Women: low socioeconomic status; women with poor personal hygiene, multiparity, early age of sexual intercourse, multiple sexual partners. Smoking, folate deficiency and other associated vulvo-vaginal infections (herpes simplex), HIV infections, immuno-deficiencies conditions are cofactors.

Causative Agent: The main cause of cervical cancer is human papilloma virus (HPV). It is passed from one person to another during sex. These viral infections clears off in most by itself, but persist in some due to unknown reasons and results into cancer.

Sign & Symptoms

Abnormal vaginal bleeding

Post coital bleeding

Persistent discharge Per vaginum

In neglected cases (very late stages: stage IV):- persistent bleeding or bowel and bladder pressure symptoms, incontinence of urine or faeces, severe backache/bone pains.

Stage of cervix cancer

Pre-malignant stage: CIN2/3

Pre-invasive stage( 0 stage): carcinoma in situ

Stage I-IV: depending upon increasing spread of disease tumor is classified into higher stages

Diagnostic test

Early stage: Colposcopy directed biopsy( OPD procedure)

Late stages: Direct Punch biopsy (OPD Procedure)

Treatment

Very early stages( early micro-invasion): LEEP, Cold or laser knife conisation, simple hysterectomy

Late early Stages (stage IA2, IB1,IB2 , IIA): Surgical treatment in form of Radical hysterectomy cancer; that is removal of cervix with adjacent tissues and draining lymph nodes ( Wertheim's hysterectomy with retroperitoneal lymph node dissection) with or without adjuvant tailored pelvic radiotherapy. Late stages( Stage IIB to III B): Radiotherapy with concurrent chemotherapy

Very late stages (Stage IV): Palliative RT

Prognosis

Stage IA : 95-98%

Stage IB : 79-90%

Stage II : 70-77%

Stage III : 45%

StageIV : 12-22%

Prevention: regular Pap's smear in reproductive age group women after marriage, HPV DNA testing, if suspicious for abnormality is found colposcopy and directed biopsy is done. Recently introduced HPV vaccine is FDA approved for school going girls (9-15yrs) for prevention of cancer cervix, but it is not to be replaced by regular Pap's smear.

Photograph of Specimen removed of Radical Hysterectomy with pelvic Lymph node dissection

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